KCNJ2

KCNJ2
Identifikatori
Aliasi	KCNJ2
Vanjski ID-jevi	OMIM: 600681 MGI: 104744 HomoloGene: 20249 GeneCards: KCNJ2
Lokacija gena (čovjek) Hrom. Hromosom 17 (čovjek)[1] Bend 17q24.3 Početak 70,168,673 bp[1] Kraj 70,180,044 bp[1]
Lokacija gena (miš) Hrom. Hromosom 11 (miš)[2] Bend 11 E2|11 75.23 cM Početak 110,956,990 bp[2] Kraj 110,967,647 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization • voltage-gated ion channel activity • vezivanje identičnih proteina • phosphatidylinositol-4,5-bisphosphate binding • inward rectifier potassium channel activity • G-protein activated inward rectifier potassium channel activity Ćelijska komponenta • integral component of membrane • rough endoplasmic reticulum • Golđijev aparat • membrana • Interkalirani disk • T-tubule • voltage-gated potassium channel complex • ćelijska membrana • dendritična kičma • integral component of plasma membrane • smooth endoplasmic reticulum • soma • dendrit • intrinsic component of membrane Biološki proces • cardiac muscle cell action potential • regulation of ion transmembrane transport • magnesium ion transport • cardiac muscle cell action potential involved in contraction • ion transport • GO:0097301 cellular potassium ion homeostasis • potassium ion transport • regulation of cardiac muscle cell contraction • cellular response to mechanical stimulus • membrane repolarization during action potential • potassium ion transmembrane transport • positive regulation of potassium ion transmembrane transport • regulation of skeletal muscle contraction via regulation of action potential • regulation of resting membrane potential • regulation of membrane repolarization • relaxation of skeletal muscle • regulation of heart rate by cardiac conduction • membrane repolarization during cardiac muscle cell action potential • protein homotetramerization • relaxation of cardiac muscle • membrane depolarization during cardiac muscle cell action potential • potassium ion import across plasma membrane • cardiac conduction Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	3759	16518
Ensembl	ENSG00000123700	ENSMUSG00000041695
UniProt	P63252	P35561
RefSeq (mRNK)	NM_000891	NM_008425
RefSeq (bjelančevina)	NP_000882	NP_032451
Lokacija (UCSC)	Chr 17: 70.17 – 70.18 Mb	Chr 11: 110.96 – 110.97 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

K_ir2.1 usmjerivač kalij-ionskog kanala prema unutra je lipidno usidreni kanal kodiran genom KCNJ2.^[5][6][7][8]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 427 aminokiselina, a molekulska težina 48.288 Da.^[9]

Simboli

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000123700 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000041695 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Hansen, SB (maj 2015). "Lipid agonism: The PIP2 paradigm of ligand-gated ion channels". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1851 (5): 620–8. doi:10.1016/j.bbalip.2015.01.011. PMC 4540326. PMID 25633344.
6. ^ Raab-Graham KF, Radeke CM, Vandenberg CA (1994). "Molecular cloning and expression of a human heart inward rectifier potassium channel". NeuroReport. 5 (18): 2501–5. doi:10.1097/00001756-199412000-00024. PMID 7696590.
7. ^ Derst C, Karschin C, Wischmeyer E, Hirsch JR, Preisig-Müller R, Rajan S, Engel H, Grzeschik K, Daut J, Karschin A (2001). "Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits". FEBS Lett. 491 (3): 305–11. doi:10.1016/S0014-5793(01)02202-5. PMID 11240146. S2CID 14452157.
8. ^ Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. S2CID 11588492.
9. ^ "UniProt, P63252". Pristupljeno 25. 6. 2021.